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The Chamorros, Guam’s indigenous people, first populated the island approximately 4,000 years ago. The island has a long history of European colonialism, beginning with its discovery by Ferdinand Magellan during a Spanish expedition on March 6, 1521. The first colony was established in 1668 by Spain with the arrival of settlers including Padre San Vitores, a Catholic missionary. For more than two centuries Guam was an important stopover for the Spanish Manila Galleons that crossed the Pacific annually. The island was controlled by Spain until 1898, when it was surrendered to the United States during the Spanish-American War and later formally ceded as part of the Treaty of Paris.
[ ref: All about the state of Guam]